The Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms influence the late inflammatory response in human endotoxemia.
نویسندگان
چکیده
Polymorphisms Influence the Late Inflammatory Response in Human Endotoxemia, Claudia Marsik, Bernd Jilma, Christian Joukhadar, Christine Mannhalter, Oswald Wagner, and Georg Endler ( Department of Clinical Pharmacology and 2 Institute of Medical and Chemical Laboratory Diagnostic, Medical University of Vienna, Vienna, Austria; * address correspondence to this author at: Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Wien, Austria; fax 43-1-40400, ext. 2998, e-mail [email protected])
منابع مشابه
Interleukin-17 Serum Levels and TLR4 Polymorphisms in Ulcerative Colitis
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متن کاملارتباط پلی‌مورفیسم‌های ژنتیکی پذیرنده شبه Toll 4 (TLR4) و استعداد ابتلا به سل ریوی
Background & Aim: Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) are the members of the Toll-like receptor family and play important roles in recognition and subsequent immune response against mycobacteria. Two functional polymorphisms for TLR2 (Arg677Trp, C à T Arg753Gln, G à A) and TLR4 (Asp299Gly, A à G Thr399Ile, C à T) genes have been associated with a negative influence on ...
متن کاملLack of genetic association of the Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms with spondylarthropathies in a Hungarian population.
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متن کاملAssociation of toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms with increased infection risk in patients with advanced HIV-1 infection.
BACKGROUND. The Toll-like receptor 4 (TLR4) is an essential component of the innate immune response to various microorganisms. We investigated the association between TLR4 polymorphism and the risk of acquiring severe infections, in patients with human immunodeficiency virus (HIV)-1 infection. METHODS. The presence of TLR4 Asp299Gly and Thr399Ile single nucleotide polymorphisms (SNPs) was deter...
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عنوان ژورنال:
- Clinical chemistry
دوره 51 11 شماره
صفحات -
تاریخ انتشار 2005